The genome-wide risk alleles for psychiatric disorders at 3p21. 1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine
Z Yang, D Zhou, H Li, X Cai, W Liu, L Wang… - Molecular …, 2020 - nature.com
… analyses combining expression quantitative trait loci (eQTL) … was the quantitative readout
representing cognitive abilities. … of psychosis), or depression, as well as in their relatives [7–…
representing cognitive abilities. … of psychosis), or depression, as well as in their relatives [7–…
Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals
… with either expression quantitative trait loci or chromatin … correlations with depressive
symptoms and schizophrenia. There were … EMR smoking data consist of text values that represent …
symptoms and schizophrenia. There were … EMR smoking data consist of text values that represent …
Interrogating the genetic determinants of Tourette's syndrome and other tic disorders through genome-wide association studies
, … Association of America International … - American Journal of …, 2019 - Am Psychiatric Assoc
… cortex and for methylation quantitative trait loci (mQTLs) in … from simplex families without
affected first-degree relatives, we … from multiplex families (positive for first-degree relative family …
affected first-degree relatives, we … from multiplex families (positive for first-degree relative family …
… of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU …
D Quattrone, U Reininghaus, AL Richards… - Translational …, 2021 - nature.com
… Supporting this, in a dimensional representation of psychosis, … statistics from large
genome-wide association studies (GWAS) … [58], in the Roscommon family study [59], and …
genome-wide association studies (GWAS) … [58], in the Roscommon family study [59], and …
Why does age of onset predict clinical severity in schizophrenia? A multiplex extended pedigree study
… with at least 2 relatives diagnosed with schizophrenia and … bivariate heritabilities, which
represent the total genetic effect … overall heritability of specific symptom dimensions. Our study …
represent the total genetic effect … overall heritability of specific symptom dimensions. Our study …
Genetic contribution to the aggregation of schizophrenia and bipolar disorder in multiplex consanguineous Pakistani pedigrees
Q He - 2019 - papyrus.bib.umontreal.ca
… using genome-wide linkage analysis in schizophrenia and … Typical family designs of linkage
include: parent–offspring … from the extremes of a quantitative trait distribution (for example, …
include: parent–offspring … from the extremes of a quantitative trait distribution (for example, …
Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism
… Here, we performed a genome-wide association study (GWAS… , we used two expression
quantitative trait loci (eQTL) datasets … ASD in multiplex families as compared to simplex families. …
quantitative trait loci (eQTL) datasets … ASD in multiplex families as compared to simplex families. …
Genetic contributions to transdiagnostic symptom dimensions in patients with major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders
… Second, genome-wide association studies (GWAS) were … As demonstrated by twin and family
studies, each of the disorders has a … Bipolar multiplex families have an increased burden of …
studies, each of the disorders has a … Bipolar multiplex families have an increased burden of …
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction
F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
… genome-wide association study, MHC the major histocompatibility complex, cQTL chromatin
quantitative trait … , and HCN families) involved in schizophrenia pathophysiology are reliable …
quantitative trait … , and HCN families) involved in schizophrenia pathophysiology are reliable …
[HTML][HTML] The genetic basis of onset age in schizophrenia: evidence and models
… for psychosis, and as an important phenotypic dimension of … a genome-wide scan of AAO
among 295 families with … were under-represented in schizophrenia patients compared with …
among 295 families with … were under-represented in schizophrenia patients compared with …